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Dorohedoro takes place in two worlds. The Hole is a grimy, polluted city where ordinary humans live, and sorcerers regularly come through magic doors to practice their spells on the people there. The sorcerers' own world is a gloomy class society dominated by En, a powerful crime boss. The story follows Caiman, a man in the Hole who has a reptile's head and no memory of who he was, and his friend Nikaido as they hunt sorcerers to find the one who changed him. The cast falls into two main groups: Caiman's allies in the Hole, and En's organisation, the En Family, whose members start looking for Caiman. This page covers 10 characters from both sides, with their roles, magic and Japanese voice actors. The series is violent and darkly comic, so it suits older teens and adults.
The protagonist. A sorcerer's spell left him with a reptile's head and wiped his memory, so he does not know his real face or name. He works at Vaux's clinic and spends his nights catching sorcerers, testing each one to find the person who cursed him and undo the spell. He is a skilled knife fighter and magic has no effect on him. Easygoing between fights, he is a regular at Nikaido's restaurant. Voiced by Wataru Takagi.
Caiman's closest friend. She runs the Hungry Bug, a small restaurant in the Hole, and joins Caiman on his sorcerer hunts because she wants to help him get his memory and face back. She fights with martial arts rather than magic, is quick on her feet and keeps her friend grounded. Cheerful and practical, she worries about Caiman's habit of rushing into danger. Voiced by Reina Kondō.
One of En's top cleaners and Noi's partner and best friend. His magic lets him take apart whatever he touches, which makes him one of the most dangerous people Caiman can run into. Calm and methodical, he follows En's orders without fuss and rarely loses his temper. His partnership with Noi is one of the closest bonds in the series. Voiced by Yoshimasa Hosoya.
Shin's partner and En's younger cousin. Her magic heals wounds, which makes her one of the most valued members of the En Family, and she is also very strong in a straight fight. She and Shin handle the jobs En trusts to no one else. Outside work she is relaxed and friendly, and she is fiercely loyal to Shin. Voiced by Yū Kobayashi.
A scientist in the Hole who has studied sorcerers for decades. He owns an artificial door that can reach the sorcerers' world, which makes him a valuable ally for Caiman and Nikaido. Curious to a fault, he treats every strange case as research material. His assistant is the giant insect Jonson. Voiced by Mitsuhiro Ichiki.
Professor Kasukabe's sidekick: a giant cockroach that grew to an enormous size in the Hole's polluted water. He can only say one word, 'shocking', yet he is strong and useful in a fight. He is one of the series' running jokes and shows the odd humour mixed into its dark setting. Voiced by Ryōhei Kimura.
A doctor who runs a clinic in the Hole for people changed or hurt by sorcerers' magic. He is easy to spot: bald, with a blue grid tattoo across his face and head. He employs Caiman as an assistant, which gives Caiman a steady job between hunts, and he sees the damage sorcerers cause every day. Voiced by Hisao Egawa.
A low-ranking sorcerer working for En's company. He lost his work partner in a fight with Caiman in the first episode and wants to settle the score by tracking down whoever is behind Caiman. His magic is weak, so he often ends up in over his head, which makes him one of the funnier figures among the sorcerers. He spends much of his time with Ebisu. Voiced by Kengo Takanashi.
A teenage sorcerer in a skull-shaped mask who works for the En Family. After she is badly hurt in an encounter with Caiman, her memory and behaviour are scrambled, and she drifts between confusion and odd outbursts. Fujita rescues her and ends up looking after her, and she grows a grudging fondness for him. Her strange remarks are a regular source of comedy. Voiced by Miyu Tomita.
The boss of the En Family, a sorcerer who runs a business empire and much of his world's criminal underworld. His magic is tied to mushrooms, and his power and money make him the most feared figure among the sorcerers. Proud and quick to anger, he keeps a team of skilled cleaners to handle his problems. He takes an interest in Caiman early in the story. Voiced by Kenyu Horiuchi.
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